Angiotensin-converting enzyme gene rs4343 polymorphism increases susceptibility to migraine

Angiotensin-converting enzyme gene insertion/deletion polymorphism in migraine patients

BACKGROUND The main objective of this study was to investigate the angiotensin converting enzyme (ACE) genotype as a possible risk factor for migraine (both with and without aura) compared to controls. We also wanted to examine whether a clinical response to an ACE inhibitor, lisinopril, or an angiotensin II receptor blocker, candesartan, in migraine prophylaxis was related to ACE genotype. M...

Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes

Background: Angiotensin I converting enzyme (ACE) is a Zinc metalloproteinase, converts Ang-I to Ang- II, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes. Objective: To investigate the relationship between ACE I/D polymorphism and type 2 diabetes in 261 Iranian casecontrol pairs. Methods: 170 patients (85 type 2 diabetics with nephropathy a...

Angiotensin-converting enzyme I/D polymorphism and susceptibility of psoriasis

The role of angiotensin-converting enzyme (ACE) I/D polymorphism in psoriasis have not been determined. Thus, in this study, we aimed to analyse ACE I/D polymorphism for the association with the risk of psoriasis in a Chinese Han population. A total of 161 cases (72 men and 89 women; mean age, 43.8 ± 5.5 years) and 256 controls (119 men and 137 women; mean age, 42.1 ± 6.9 years) were included i...

Angiotensin Converting Enzyme in Sarcoidosis

Evaluation of angiotensin converting enzyme gene polymorphism and susceptibility to bronchial asthma among Egyptians.

BACKGROUND Angiotensin converting enzyme (ACE) is expressed at high levels in the lungs and plays a role in the metabolism of the endogenous peptides involved in asthma pathogenesis. ACE gene polymorphisms have been reported to be linked to asthma. However, the results are conflicting, with no reported studies on Egyptian asthmatics. We aimed to assess ACE gene polymorphism among Egyptian asthm...